This research project concentrates on the design, development, and evaluation of a bio-ionic platform that facilitates physiological studies through continuous and real-time monitoring of cellular ionic activities. This platform functions at the interface of biological cells and interacts with the cells’ bioenvironment, enabling the monitoring of various biological attributes such as metabolism, growth, stress response, damage repair, physiology, and development, as these attributes are reflected in the cells’ ionic activities. The outcome of the research will serve as the foundation for a larger project, wherein we aim to gain a comprehensive understanding of how space environment and gravity impact cellular functions.